PROGRAMME

Arrival of Scholars and Faculty at the Certosa di Pontignano

Registration

A short guided tour through the Certosa, its Chapel, Cloisters and Garden

Opening Ceremony - Welcome Addresses

The European Pain School

Anna Maria Aloisi, School Director (Siena, Italy)

Welcome by the President of Medical School, University of Siena

The International Association for the Study of Pain (IASP)

Fernando Cervero, IASP President-Elect (Montreal, Canada)

The FENS/IBRO Neurosciences School Programme

Mihai Moldovan, Liaison Officer of the School Committee (Univ. of Copenhagen, Denmark)

Grünenthal for pain

Gaby Erkens, Scientific Relations Management Grunenthal GmbH (Aachen, Germany)

Pain a field of science

Marshall Devor (The Hebrew University, Jerusalem, Israel)

Monasteries, the medieval forerunners of Universities and Hospitals

Manfred Zimmermann (Univ. of Heidelberg, Germany)

The Certosa di Pontignano

Giancarlo Carli (Univ. of Siena, Italy)

Scholars’ self-introduction
to be continued informally at the subsequent wine reception and dinner

Guided morning exercise in the large Cloister

Breakfast

Session II

Lecture 1

Evolution of pain concepts

Manfred Zimmermann (Heidelberg, Germany)

Oral Presentations by Scholars

15. Electrophysiological characterization of a novel small peptide from the venom of Conus californicus that targets voltage-gated neuronal Ca²⁺ channels

Omar López (Puebla, Mexico)

22. Endogenous analgesia mechanism in health, in migraine and in predicting the efficacy of pharmacological intervention

Hadas Nahman-Averbuch (Haifa, Israel)

17. Mechanical hyperalgesia evoked by intrathecal administration of BDNF in rats – Comparison with mechanical hyperalgesia caused by sciatic nerve ligation

Saïd M’Dahoma (Paris, France)

21. The Bath test of attention for pain (Bath TAP): A systematic study of the interruptive effect of pain on attention

David Moore (Bath, UK)

Lecture 2

Neuronal excitability and hyperexcitability: cellular mechanisms and genetic determinants

Marshall Devor (Jerusalem, Israel)

Lunch in the small cloister

Session III

Lecture 3

Understanding pain: exploring pain mechanisms

Fernando Cervero (Montreal, Canada)

Oral Presentations by Scholars

19. Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympa-thetic neurons

Michael S. Minett (London, United Kingdom)

12. Role of sigma-1 receptor (σ1R) in postoperative pain

Georgia Gris (Barcelona, Spain)

09. A role of calcium/calmodulin-dependent protein kinase II in diabetic neuropathy

Lejla Ferhatovic (Split, Croatia)

04. Segmental noxious versus innocuous electrical stimulation for chronic pain relief and the effect of fading sensation during treatment

Efrat Ariel (Tel-Aviv, Israel)

Lecture 4

Pain: medicine and science in the 20th century

John Loeser (Seattle, USA)

Dinner in the small Cloister

Evening session (after dinner)

Behavioral Tests & Tools in Pain Research A hands-on presentation of equipment for experimental pain research

Lead by Federico Oggioni (Ugo Basile Biological Research Apparatus, Comerio, Italy)

Guided morning exercise in the large Cloister

Breakfast

Sessio IV

Lecture 5

What’s wrong with animal models of pain?

Ze’ev Seltzer (Toronto, Canada)

Oral Presentations by Scholars

20. Early-life stress induces visceral hypersensitivity in mice

Rachel Moloney (Cork, Ireland)

25. Does genetic background affect the development of streptozotocin-induced diabetic neu-ropathy in rat?

Dora Pinho (Porto, Portugal)

27. Collagen antibody-induced arthritis (CAIA) generates evoked and ongoing nociception, but transient joint inflammation

Katalin Sandor (Stockholm, Sweden)

13. The co-occurrence of pain disorders: a general pain liability or side effect of depression?

Lannie Ligthart (Amsterdam, Netherlands)

Lecture 6

Pain from inside: visceral pain, peripheral and central mechanisms

Fernando Cervero (Montreal, Canada)

Lunch in the small cloister

Session V

Lecture 7

Drugs for Pain – what are the molecules?

Mila Vlaskovska (Sofia, Bulgaria)

Oral Presentations by Scholars

28. In vitro and in vivo characterisation of P2X3/P2X2X3 antagonists for pain

Inga Schapitz (Aachen, Germany)

16. Role of JNK isoforms in the development of neuropathic pain following sciatic nerve tran-section in the mouse

Giusi Manassero (Turin, Italy)

06. Role of soluble pain mediators in cross-talk between neurons and glia within trigeminal ganglia

Tanja Bele (Nova Gorica, Slovenia)

29. Local and remote immune-inflammation after mild peripheral nerve compression in rats

Annina Schmid (St. Lucia, Australia)

Lecture 8

Pain at the crossroads of the immune and nervous systems in rats

Stephen McMahon (London, United Kingdom)

Dinner in the small Cloister

Evening session

The debating teams, established beforehand, will meet to prepare for the “Scholar’s debate” which takes place on Thursday morning.

Guided morning exercise in the large Cloister

Breakfast

Session VI

Lecture 9

Labelled lines for pain? Lessons from intraneural microstimulation in humans

Jordi Serra (Barcelona, Spain)

Oral Presentations by Scholars

01. Effects of ethnicity and gender role expectations of pain on experimentally induced pain: a cross-cultural study between Libyan and white British students

Oras Alabas (Leeds, United Kingdom)

18. A comparison of C- and A-nociceptive inputs to the different functional columns of the periaqueductal grey from areas of primary and secondary hyperalgesia in a rat model of in-flammatory pain.

Joyce Mendes Gomes (Bristol, United Kingdom)

26. ASIC channels - a new challenge in diabetic neuropathy

Beatrice Mihaela Radu (Verona, Italy )

30. The role of small RNAs in nociception

Samuel Shepherd (London, United Kingdom)

Lecture 10

The genetics and phenomics of pain

Ze’ev Seltzer (Toronto, Canada)

Lunch in the small cloister

Session VII

Lecture 11

Epigenetics of pain

Stephen McMahon (London, United Kingdom)

Special Interactive Workshop of Scholars and Faculty

Ethical motivations and limitations of pain research and treatment in humans and animals – the new European Directive

Introduction: Manfred Zimmermann (Heidelberg, Germany)

How to write a successful grant application?

Introduction: Marshall Devor (Jerusalem, Israel)

Lecture 12

Ionic channel dysfunction in pain and motor systems

Mihai Moldovan (Copenhagen, Denmark)

Dinner in the small Cloister

Guided morning exercise in the large Cloister

Breakfast

Session VII

Lecture 13

Tic douloureux and phantom limb pain: clinical phenomena and mechanisms

Duet: John Loeser (Seattle, USA) and Marshall Devor (Jerusalem, Israel)
Moderator: Jordi Serra (Barcelona, Spain)

Oral Presentations by Scholars

31. Safety and efficacy outcomes in patients with post-herpetic neuralgia - more than 5 years treatment with 5% lidocaine medicated plaster

Ingrid Tacken (Aachen, Germany)

24. Pain in amaXhosa women living with HIV/AIDS: characteristics, contributing factors and the effects of a 6-week peer-led exercise and education intervention

Romy Parker (Cape Town, South Africa)

Lecture 14

Determinants of pain sensitivity at genetic and molecular levels

Rohini Kuner (Heidelberg, Germany)

Scholars debate

Moderator: Marshall Devor (Jerusalem, Israel)

The following issues will be debated by the Scholar debate teams. Expect sharp argumentation, heat, passion and plenty of humor. Winners will be decided on the basis of audience enthusiasm:

Chronic pain is not just a disease symptom, it is a disease in its own right

Is it true that pain perception is a result of network activity in a cortical “pain matrix”?

Excursion to Siena Old Town

Bus departs from the Certosa

Guided tour to historical Siena, City Hall and Cathedral

Visit of the Art exhibition on the facial expression of pain, Sala Rosa, Aperitif

Free time for Scholars in Siena/Faculty dinner

Guided morning exercise in the large Cloister

Breakfast

Session IX

Lecture 15

Mood and attention differentially control pain

Rohini Kuner (Heidelberg, Germany)

Oral Presentations by Scholars

23. Insights into CB1 Molecular Mechanism and Its Role in Pain Perception

Christian Njoo (Heidelberg, German)

05. Modulation of biogenic amines, substance-P and neurotrophic factor produces chronic muscular pain and tactile allodynia accompanied by depression-a putative animal model of pain-depression dyad

Vipin Arora (Chandigarh, India)

03. Neonatal sleep deprivation induces hyperalgesia in adolescent mice

Paula Araujo (Sao Paulo, Brazil)

11. High levels of N-palmitoylethanolamide and N-stearoylethanolamide in microdialysate samples from myalgic human trapezius muscle

Nazdar Ghafouri (Umea, Sweden)

Lecture 16

Multiple mechanisms and comorbidities in fibromyalgia, a type of chronic widespread pain

Giancarlo Carli (Siena, Italy)

Lunch in the small cloister [free discussions and garden walks]

Session X

Lecture 17

Lessons learned from the neuroimaging of pain

Ulrike Bingel (Hamburg, Germany)

Oral Presentations by Scholars

07 .Visual stimuli within peripersonal space prioritize pain

Annick De Paepe, (Ghent, Belgium)

10. Reinstatement of the ‘pain matrix’ by neutral visual objects previously associated with pain

Katarina Forkmann (Hamburg, Germany)

02. A microneurography study in fibromyalgia

Francesca Antonelli (Barcelona, Spain)

14. Altered C-tactile processing in human dynamic tactile allodynia

Hanneke Lucia Dorothea Maria Willemen (Jaquette Liljencrantz, Gothenburg, Sweden)

Lecture 18

Dysfunction of injured nerve fibers generating neuropathic pain

Jordi Serra (Barcelona, Spain)

Dinner in the small Cloister

Guided morning exercise in the large Cloister

Breakfast

Session XI

Lecture 19

Sex steroids and genes controlling pain in the backstage of the brain

Anna Maria Aloisi (Siena, Italy)

Oral Presentations by Scholars

08. Influence of sex differences on progression of cancer-related bone pain in a murine model

Sarah Falk (Copenhagen, Denmark)

Lecture 20

Cognitive modulation of pain and analgesia, clinical implications

Ulrike Bingel (Hamburg, Germany)

Lecture 21

Opioids: a tale of two visions

John Loeser (Seattle, USA)

Lunch in the small cloister

Farewell Session

Bus Transfer to Rapolano Terme, a hot mineral water Spa in Tuscany

Stay and relax at “Terme Antica Querciolaia”, Rapolano Terme Bathing in the waters of a hot mineral spring known and used by the Romans for purposes of medicinal application, wellness, love and entertainment

Farewell dinner and party in the Terme restaurant

Bus return to the Certosa di Pontignano

Departures