PRELIMINARY PROGRAMME

Arrival of Scholars and Faculty at the Certosa di Pontignano

Assignment to single or double rooms in the hotel wing of the Certosa. All food during the week will be provided by the restaurant of the Certosa, breakfast, lunch and dinner, including wine from the Certosa’s Chianti wineyards, as well as non-alcoholic drinks, all free of extra charge

A short guided tour through the Certosa, its Chapel, Cloisters and Garden

Opening Ceremony

Siena University

President of the Medical School

The European Pain School

Anna Maria Aloisi, School Director, Siena

IASP, the World Pain Society

Rolf-Detlef Treede, President Elect

The mission of ARPA Foundation

Prof. Franco Mosca, University of Pisa

With passion against pain

Grünenthal Scientific Relations Management

Pain a field of science

Marshall Devor, Jerusalem

The Certosa di Pontignano and its history

Giancarlo Carli, Siena

Monasteries, medieval forerunners of Universities and Hospitals

Manfred Zimmermann, Heidelberg

Scholars' self-introduction followed by a wine reception and dinner

Guided morning exercise in the large Cloister

Breakfast

Morning Session

• Faculty Lecture 1
• Oral Presentations by 2 Scholars
• Coffee break on the Garden Terrace
• Oral Presentations by 2 Scholars
• Faculty Lecture 2
• Discussions conducted by Faculty and Scholar

Lunch in the small Cloister, free group discussions and garden walks

Afternoon Session

• Faculty Lecture 3
• Oral Presentations by 2 Scholars
• Coffee break on the Garden Terrace
• Oral Presentations by 2 Scholars
• Faculty Lecture 4
• Discussions conducted by Faculty and Scholar

Dinner in the small Cloister

Evening event (optional)

Schedule of Lectures (L), Workshops (W) and Scholars’ presentations Formats of teaching:
L1 – L17 Keynote Lectures, maximum 40 Min + 20 Min for discussion
W1 – W6 Interactive Workshops and Seminars
Scholar’s presentations 10 Min + 5 Min for discussion

Morning Session

L1 Spontaneous and evoked pain – a neurophysiological introduction

Manfred Zimmermann (Heidelberg, Germany)

Scholars’ oral presentations

The action of P2Y12 receptor antagonists in animal models of inflammatory, neuropathic and acute pain

Gergely Horváth (Budapest, Hungary)

Spontaneous pain in partial nerve injury models of neuropathy and the role of nociceptive sensory cover

Pine Koplovitch (Jerusalem, Israel)

Unique spatial patterns of activity for pain in human primary sensory cortices

Meng Liang (London, UK)

Activation and proliferation of satellite glial cells surrounding primary afferent neurons of monoarthritis rats: is there a role for ATF3?

Diana Nascimento (Oporto, Portugal)

L2 Hyperexcitable neurons as generators of spontaneous and evoked pain

Marshall Devor (Jerusalem, Israel)

Afternoon Session

L3 Tonic immobility response from invertebrates to vertebrates: nociception, analgesia and emotional aspects

Giancarlo Carli (Siena, Italy)

Scholars’ oral presentations

Pharmacological validation of burrowing paradigm as a non-reflex behavioral readout for analgesic action in a rat model of knee joint rheumatoid arthritis

Pascal Dowling (Aachen, Germany)

Does placebo analgesia modulate pain signaling at the spinal level?

Yvette Güereca (Tulsa, OK, USA)

Non pharmacological approach for modulation of activity in sensor neurons

Sergii Romanenko (Limoges, France)

The postnatal development of serotonergic descending control of spinal nociception

Fred Schwaller (London, UK)

L4 Pain modulation from the brain: inhibition vs facilitation

Deolinda Lima (Oporto, Portugal)

Evening session

W1 Behavioral Tests & Tools in Pain Research
A hands-on presentation of equipment for experimental pain research

Lead by Federico Oggioni, Ugo Basile Biological Research Apparatus, Comerio, Italy

Morning Session

L5 Sodium channelopathies in pain disorders: from molecule to man

Sulayman Dib Hajj (New Haven, CT, USA)

Scholars’ oral presentations

Gender difference in auditory stimulus sensitivity in patients with chronic pain

Mehdi Mark Nazemi (Surrey, UK)

Involvement of µ-opioid receptors in antinociceptive action of botulinum toxin type

Visnja Drinovac (Zagreb, Croatia)

Somatosensory assessment and rehabilitation of allodynia: the SARA pilot study

Tara Packham (Hamilton, ON, Canada)

Morphology and function of peripheral glia in primary culture of trigeminal satellite glial cells: a cell based study

Jeppe Poulsen (Aalborg, Denmark)

L6 Assessing the pain code by intraneural recording in humans

Jordi Serra (Barcelona, Spain)

Afternoon Session

L7 Assessing pain versus nociception in animals

Jeffrey Mogil (Montreal, QC, Canada)

Scholars’ oral presentations

Contingent negative variation in conditioned analgesia

Alessandro Piedimonte (Turin, Italy)

Molecular mechanisms underlying spontaneous pain and mechanical hypersensitivity in Osteoarthritis

Jane Sexton (London, UK)

Steroidal and non-steroidal third-generation aromatase inhibitors, exemestane and lerozole, induce pain via TRPA1 activation

Gabriela Trevisan (Tucson, AZ, USA)

Comparison of evoked and non-evoked pain readouts in rats with CFA-induced sub-chronic knee joint inflammation

Markus Valdor (Aachen, Germany)

L8 Symptoms and mechanisms of headache

Piero Geppetti (Florence, Italy)

Morning Session

L9 What about pain genes?

Jeffrey Mogil (Montreal, QC, Canada)

Scholars’ oral presentations

Sex differences in collagen antibody induced arthritis and allodynia in mice

Tianle Gao (Stockholm, Sweden)

Role of the gene FKBP5 in different pain animal models

Maria Maiaru’ (London, UK)

Pain education and self management for persistent pain: a randomized trial and clinical prediction rule

Jordan Miller (London, Ontario, Canada)

Mice lacking the vasopressin V1b receptor present thermal hypoalgesia and exacerbated vasopressin-induced analgesia

Julio Cesar Morales-Medina (Kent, Ohio, USA)

L10 Hormone modulation of pain

Anna Maria Aloisi (Siena, Italy)

Afternoon Session

L11 New and old sodium channel blockers: advances and implications for treatment of pain

Sulayman Dib Hajj (New Haven, USA)

W2 A duetto on pain - sensation and suffering

Jeff Mogil & Jordi Serra, moderated by Marshall Devor

L12 Headache pathobiology: channels and genes

Piero Geppetti (Florence, Italy)

Morning Session

L13 Brain imaging studies on percept-related activity in the human pain system

Carlo Porro (Modena, Italy)

Scholars’ oral presentations

Influence of pain relevant versus pain irrelevant anxiety on observers’ pain

Adriana Banozic (Split, Croatia)

Orbitofrontal cortex mediates the interaction of pain and reward

Susanne Becker (Montreal, Quebec, Canada)

Prolonged continuous theta-burst stimulation leads to more analgesia than classical high frequency repetitive transcranial magnetic stimulation

Xavier Moisset (Boulogne Billancourt, France)

Acting on pain: evidence from healthy subjects and HSAN-V carriers

Irene Perini (Gothenburg, Sweden)

W3 Ethical motivations and limitations of pain research and treatment in humans and animals

Manfred Zimmermann (Heidelberg, Germany)

• Declaration of Helsinki
• EU Directive for the use of animals in research
• IASP Guidelines for pain research on humans and animals

Afternoon and Evening

Excursion to Siena old town

15:00-18:00 Guided tour to historical Siena, visit of the Cathedral and City Hall

18:00-24:00 Free time for Scholars in Siena / Faculty Dinner

Morning Session

L14 Nervous system gain control of pain sensitivity

Rolf-Detlef Treede (Heidelberg, Germany)

Scholars’ oral presentations

Psychological and physical pain in adults with autism spectrum disorder: a psychophysical and neuroimaging study

Joana Carvalho (Oporto, Portugal)

The dynamics of pain: Evidence for simultaneous site-specific habituation and site-nonspecific sensitization in thermal pain

Marieke Jepma (Boulder Colorado, USA)

Aberrant fMRI responses to multisensory events classify fibromyalgia patients: a machine learning approach

Marina López-Solà (Boulder, Colorado, USA)

Psychophysical and patient factors as determinants of pain, function and health status in shoulder disorders

Zakir Uddin (Hamilton, Ontario, Canada)

L15 Brain correlates of placebo-induced analgesia

Carlo Porro (Modena, Italy)

Afternoon Session

L16 The disruptive effect of pain on attention: Translations from the clinic to the lab and back again

Edmund Keogh (Bath, UK)

Scholars’ oral presentations

Serum level of brain-derived neurotrophic factor in fibromyalgia syndrome correlates with depression but not anxiety

Boya Nugraha (Hannover, Germany)

Does pain smell bad? - Cross-modal anticipatory effects between nociception and olfaction: fMRI study in humans

Gil Sharvit (Geneva, Switzerland)

W4 Experiments in the pain laboratory – sensory dissociation during limb ischemia

Jordi Serra (Barcelona, Spain)

Morning Session

L17 Pain mechanisms in male and female subjects – Old mistakes and new approaches

Anna Maria Aloisi (Siena, Italy)

W5 Scholars’ controversial debates on the following topics

Marshall Devor (Moderator)

1. Resolved: “Pain perception is a result of network activity in the cerebral cortex rather than, say, activity in a focal primary pain cortex (P1)”
2. Resolved: “There is no really effective drug for neuropathic pain because we rely too much on animal models”

W6 Evaluations of EPS 2014 by Scholars and Faculty
Questionnaire, general discussion of the EPS experience and suggestions on how to modify/improve EPS in the future

Afternoon and Night

16:00-24:00 Farewell Session and Dinner in the Certosa

Scholars and Faculty are invited to provide/organize some enterpainment

Departure from the Certosa di Pontignano